Do I need to make a different CV for every job I apply for?

Almost certainly. Even if you’re applying for exactly the same position with a variety of different employers, the differences between the employers themselves make it worthwhile tweaking your CV to make it appeal to each one. But most job-seekers, whatever their industry and level, tend to apply for a range of different jobs, each with its own different core requirements and emphasis, and it’s always worth producing a brand-new CV with the needs of that job and that organisation in mind.